Chimeric Antigen Receptor T-cell Therapy for Multiple Myeloma.
Clin Lymphoma Myeloma Leuk
; 21(1): 21-34, 2021 01.
Article
em En
| MEDLINE
| ID: mdl-33046423
ABSTRACT
Relapsed/refractory multiple myeloma (MM) remains a significant clinical challenge, despite a wide array of approved therapeutic agents. Immunotherapy offers an advantage in this setting. Chimeric antigen receptor (CAR) modified T-cells have transformed care for patients with hematologic malignancies. CAR-T cells targeting CD-19 B-cell lymphoma cells have shown prominent activity in lymphoma and acute lymphoblastic leukemia. Recently, the CAR-T cell platform for MM demonstrated therapeutic benefit. Hence, it is rapidly progressing. The most commonly tested target for MM is the B-cell maturation antigen. Complexities involved in the generation and use of CAR-T cells for MM include the identification of appropriate target antigens that are specific, and tumor type restricted, in addition to the optimization of CAR constructs to mitigate toxicities including cytokine release syndrome. CAR-T cells hold immense promise as a therapeutic modality for the treatment of MM. In this article, we provide an updated review of clinical trials of MM-specific CAR-T cells.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
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Terapia Baseada em Transplante de Células e Tecidos
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Receptores de Antígenos Quiméricos
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Mieloma Múltiplo
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article