Stimuli-responsive and cellular targeted nanoplatforms for multimodal therapy of skin cancer.
Eur J Pharmacol
; 890: 173633, 2021 Jan 05.
Article
em En
| MEDLINE
| ID: mdl-33049302
ABSTRACT
Interdisciplinary applications of nanopharmaceutical sciences have tremendous potential for enhancing pharmacokinetics, efficacy and safety of cancer therapy. The limitations of conventional therapeutic platforms used for skin cancer therapy have been largely overcome by the use of nanoplatforms. This review discusses various nanotechnological approaches experimented for the treatment of skin cancer. The review describes various polymeric, lipidic and inorganic nanoplatforms for efficient therapy of skin cancer. The stimuli-responsive nanoplatforms such as pH-responsive as well as temperature-responsive platforms have also been reviewed. Different strategies for potentiating the nanoparticles application for cancer therapy such as surface engineering, conjugation with drugs, stimulus-responsive and multimodal effect have also been discussed and compared with the available conventional treatments. Although, nanopharmaceuticals face challenges such as toxicity, cost and scale-up, efforts put-in to improve these drawbacks with continuous research would deliver exciting and promising results in coming days.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
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Terapia Combinada
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Nanopartículas
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Terapia de Alvo Molecular
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Polímeros Responsivos a Estímulos
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article