Biocompatible and self-recoverable succinoglycan dialdehyde-crosslinked alginate hydrogels for pH-controlled drug delivery.
Carbohydr Polym
; 250: 116934, 2020 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-33049846
ABSTRACT
We fabricated polysaccharide-based hydrogels, which are biocompatible, self-recoverable and pH-sensitive. Succinoglycan dialdehyde (SGDA) was first synthesized from bacterial succinoglycan directly isolated from Sinorhizobium meliloti and then hydrazine-functionalized alginate (HZ-Alg) was prepared to form SGDA-crosslinked alginate hydrogels (SGDA/HZ-Alg) without any catalyst. Due to structural characteristics of SGDA, SGDA/HZ-Alg were effectively obtained in a short time even at low concentrations (0.94-1.57 wt%) where they exhibited self-recoverable and tunable rheological properties corresponding to efficiency of recovery from 93.2%-97.9%. Moreover, SGDA/HZ-Alg showed the pH-responsive degradation as well as pH-controlled release behavior for 5-fluorouracil. 5-Fluorouracil was released approximately 98 % at pH 2.0 within 12 h, but not completely released even after 24 h at pH 7.4. The WST-8 assay results also demonstrated that SGDA/HZ-Alg did not show any cytotoxicity against HEK-293 cells. Since the suggested hydrogels are biocompatible, rheologically self-recoverable and tunable, and pH-controllable, they would be potential biomaterials for the hydrogel-based drug delivery systems.
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MEDLINE
Assunto principal:
Polissacarídeos Bacterianos
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Sistemas de Liberação de Medicamentos
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Hidrogéis
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Proliferação de Células
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Alginatos
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Fluoruracila
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article