Lepidium meyenii Walpers polysaccharide and its cationic derivative re-educate tumor-associated macrophages for synergistic tumor immunotherapy.

Guo, Tingting; Yang, Ye; Gao, Mingju; Qu, Yuan; Guo, Xiaoxi; Liu, Yuan; Cui, Xiuming; Wang, Chengxiao

Guo, Tingting; Yang, Ye; Gao, Mingju; Qu, Yuan; Guo, Xiaoxi; Liu, Yuan; Cui, Xiuming; Wang, Chengxiao.

Afiliação

Guo T; School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China; Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming, 650500, China.
Yang Y; School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China; Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming, 650500, China.
Gao M; Wenshan University, Yunnan Province, Wenshan, 663000, China.
Qu Y; School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China; Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming, 650500, China.
Guo X; School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.
Liu Y; School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China; Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming, 650500, China.
Cui X; School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China; Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming, 650500, China. Electronic address: sanqi37@vip.sina.com.
Wang C; School of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China; Key Laboratory of Sustainable Utilization of Panax Notoginseng Resources of Yunnan Province, Kunming, 650500, China. Electronic address: wcx1192002@126.com.

Carbohydr Polym ; 250: 116904, 2020 Dec 15.

Article em En | MEDLINE | ID: mdl-33049880

Assuntos

Neoplasias da Mama/tratamento farmacológico; Carboidratos da Dieta/farmacologia; Fatores Imunológicos; Lepidium/química; Extratos Vegetais/farmacologia; Polissacarídeos/farmacologia; Macrófagos Associados a Tumor/imunologia; Animais; Apoptose; Neoplasias da Mama/imunologia; Neoplasias da Mama/metabolismo; Neoplasias da Mama/patologia; Proliferação de Células; Citocinas/metabolismo; Feminino; Humanos; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Nus; NF-kappa B/metabolismo; Células Tumorais Cultivadas; Macrófagos Associados a Tumor/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

Cationization; Immunotherapy; Lepidium meyenii Walp.; Polysaccharides; Tumor-associated macrophages

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polissacarídeos / Neoplasias da Mama / Carboidratos da Dieta / Extratos Vegetais / Lepidium / Macrófagos Associados a Tumor / Fatores Imunológicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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