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Offensive Behavior, Striatal Glutamate Metabolites, and Limbic-Hypothalamic-Pituitary-Adrenal Responses to Stress in Chronic Anxiety.
Ullmann, Enrico; Chrousos, George; Perry, Seth W; Wong, Ma-Li; Licinio, Julio; Bornstein, Stefan R; Tseilikman, Olga; Komelkova, Maria; Lapshin, Maxim S; Vasilyeva, Maryia; Zavjalov, Evgenii; Shevelev, Oleg; Khotskin, Nikita; Koncevaya, Galina; Khotskina, Anna S; Moshkin, Mikhail; Cherkasova, Olga; Sarapultsev, Alexey; Ibragimov, Roman; Kritsky, Igor; Fegert, Jörg M; Tseilikman, Vadim; Yehuda, Rachel.
Afiliação
  • Ullmann E; Department of Pediatric Psychiatry, Psychotherapy and Psychosomatics, University of Leipzig, 04107 Leipzig, Germany.
  • Chrousos G; Department of Medicine, Technical University of Dresden, 01309 Dresden, Germany.
  • Perry SW; School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
  • Wong ML; School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
  • Licinio J; University Research Institute of Maternal and Child Health and Precision Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Bornstein SR; College of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
  • Tseilikman O; College of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
  • Komelkova M; College of Medicine, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
  • Lapshin MS; Department of Medicine, Technical University of Dresden, 01309 Dresden, Germany.
  • Vasilyeva M; Rayne Institute, Division of Diabetes & Nutritional Sciences, Endocrinology and Diabetes, Faculty of Life Sciences & Medicine, Kings College London, London SE5 9PJ, UK.
  • Zavjalov E; School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
  • Shevelev O; Department of Fundamental Medicine, Chelyabinsk State University, 454001 Chelyabinsk, Russia.
  • Khotskin N; School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
  • Koncevaya G; School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
  • Khotskina AS; School of Medical Biology, South Ural State University, 454080 Chelyabinsk, Russia.
  • Moshkin M; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.
  • Cherkasova O; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.
  • Sarapultsev A; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.
  • Ibragimov R; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.
  • Kritsky I; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.
  • Fegert JM; Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.
  • Tseilikman V; Biophysics Laboratory, Institute of Laser Physics, Siberian Branch of the Russian Academy of Science, 630090 Novosibirsk, Russia.
  • Yehuda R; Institute of Natural Sciences and Mathematics, Ural Federal University named after the first President of Russia, 620026 Ekaterinburg, Russia.
Int J Mol Sci ; 21(20)2020 Oct 09.
Article em En | MEDLINE | ID: mdl-33050201
ABSTRACT
Variations in anxiety-related behavior are associated with individual allostatic set-points in chronically stressed rats. Actively offensive rats with the externalizing indicators of sniffling and climbing the stimulus and material tearing during 10 days of predator scent stress had reduced plasma corticosterone, increased striatal glutamate metabolites, and increased adrenal 11-dehydrocorticosterone content compared to passively defensive rats with the internalizing indicators of freezing and grooming, as well as to controls without any behavioral changes. These findings suggest that rats that display active offensive activity in response to stress develop anxiety associated with decreased allostatic set-points and increased resistance to stress.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ansiedade / Sistema Hipófise-Suprarrenal / Estresse Psicológico / Ácido Glutâmico / Corpo Estriado / Hipotálamo / Sistema Límbico Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ansiedade / Sistema Hipófise-Suprarrenal / Estresse Psicológico / Ácido Glutâmico / Corpo Estriado / Hipotálamo / Sistema Límbico Idioma: En Ano de publicação: 2020 Tipo de documento: Article