Apoptosis, autophagy and atherosclerosis: Relationships and the role of Hsp27.
Pharmacol Res
; 166: 105169, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33053445
ABSTRACT
Atherosclerosis is a multifactorial chronic inflammatory disease of the arterial wall, and an important pathological basis of coronary heart disease. Endothelial cells, vascular smooth muscle cells, and macrophages play important roles in the development of atherosclerosis. Of note, apoptosis and autophagy, two types of programmed cell death, influence the development and progression of atherosclerosis via the modulation of such cells. The small heat shock protein Hsp27 is a multifunctional protein induced by various stress factors and has a protective effect on cells. A large number of studies have demonstrated that Hsp27 plays an important role in regulating apoptosis. Recently, some studies have suggested that Hsp27 also participates in the autophagic process. Moreover, Hsp27 is closely related to the occurrence and development of atherosclerosis. Here, we summarize the molecular mechanisms of apoptosis and autophagy and discuss their effects on endothelial cells, vascular smooth muscle cells, and macrophages in the context of atherosclerotic procession. We further explore the involvement of Hsp27 in apoptosis, autophagy, and atherosclerosis. We speculate that Hsp27 may exert its anti-atherosclerotic role via the regulation of apoptosis and autophagy; this may provide the basis for the development of new approaches for the prevention and treatment of atherosclerosis.
Palavras-chave
7-Ketocholesterol (CID: 91474); AMP (CID: 6083); ATP (CID: 5957); Cholesterol (CID: 5997); Coronary artery disease; Cytokines; Endothelial cells; GTP (CID: 135398633); Glutathione (CID: 124886); Homocysteine (CID: 91552); Hydrogen peroxide (CID: 784); Macrophages; Nitric oxide (CID: 145068); Rapamycin (CID: 5284616); Transcription factors; Vascular smooth muscle cells
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Apoptose
/
Chaperonas Moleculares
/
Aterosclerose
/
Proteínas de Choque Térmico HSP27
/
Proteínas de Choque Térmico
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article