Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors.

McNeil, Matthew B; O'Malley, Theresa; Dennison, Devon; Shelton, Catherine D; Sunde, Bjorn; Parish, Tanya

McNeil, Matthew B; O'Malley, Theresa; Dennison, Devon; Shelton, Catherine D; Sunde, Bjorn; Parish, Tanya.

Afiliação

McNeil MB; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
O'Malley T; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Dennison D; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Shelton CD; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Sunde B; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA.
Parish T; TB Discovery Research, Infectious Disease Research Institute, Seattle, Washington, USA tanya.parish@seattlechildrens.org.

mSphere ; 5(5)2020 10 14.

Article em En | MEDLINE | ID: mdl-33055263

Assuntos

Antibacterianos/farmacologia; Proteínas de Bactérias/antagonistas & inibidores; Proteínas de Bactérias/genética; Farmacorresistência Bacteriana/genética; Proteínas de Membrana Transportadoras/genética; Mycobacterium tuberculosis/efeitos dos fármacos; Mycobacterium tuberculosis/genética; Transporte Biológico/efeitos dos fármacos; Parede Celular/efeitos dos fármacos; Humanos; Testes de Sensibilidade Microbiana; Mutação; Tuberculose/microbiologia

Palavras-chave

antibiotic resistance; cell wall; drug discovery; mechanism of resistance; mode of action; mycobacteria; mycolic acids

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Membrana Transportadoras / Proteínas de Bactérias / Farmacorresistência Bacteriana / Antibacterianos / Mycobacterium tuberculosis Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google