Effect of folate on phenytoin hyperplasia.
J Clin Periodontol
; 14(6): 350-6, 1987 Jul.
Article
em En
| MEDLINE
| ID: mdl-3305590
ABSTRACT
There have been some reports that folic acid inhibits phenytoin-induced gingival hyperplasia. The purpose of this double-blind study was to quantify clinically the effects of both systemic and topical administration of folic acid on phenytoin-induced gingival overgrowth in man. For a period of 6 months, one group of phenytoin patients received 2 daily topical applications of a folate solution. An additional group received 2 daily doses of systemic folate while a control group received placebo medication. Results indicate that throughout the 180-day period of the study, the topical folate significantly inhibited gingival hyperplasia to a greater extent than either systemic folate or placebo groups.
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Base de dados:
MEDLINE
Assunto principal:
Fenitoína
/
Ácido Fólico
/
Hiperplasia Gengival
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article