Pharmacological inhibition of Kv3 on oxidative stress-induced cataract progression.
Biochem Biophys Res Commun
; 533(4): 1255-1261, 2020 12 17.
Article
em En
| MEDLINE
| ID: mdl-33066958
ABSTRACT
Oxidative stress is one of the most important risk factors for cataractogenesis. Previous studies have indicated that BDS-II, a Kv3 channel blocker, plays pivotal roles in oxidative stress-related diseases. This study demonstrates that BDS-II exerts a protective effect on cataractogenesis. Specifically, BDS-II was observed to inhibit lens opacity induced by H2O2. BDS-II was also determined to inhibit cataract progression in a sodium selenite-induced in vivo cataract model by inhibiting reduction of the total GSH. In addition, BDS-II was demonstrated to protect human lens epithelial cells against H2O2-induced cell death. Our results suggest that BDS-II is a potential pharmacological candidate in cataract therapy.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Catarata
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Estresse Oxidativo
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Bloqueadores dos Canais de Potássio
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Canais de Potássio Shaw
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article