Investigating the antibacterial activity of salen/salophene metal complexes: Induction of ferroptosis as part of the mode of action.

Baecker, Daniel; Sesli, Özcan; Knabl, Ludwig; Huber, Silke; Orth-Höller, Dorothea; Gust, Ronald

Baecker, Daniel; Sesli, Özcan; Knabl, Ludwig; Huber, Silke; Orth-Höller, Dorothea; Gust, Ronald.

Afiliação

Baecker D; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020, Innsbruck, Austria.
Sesli Ö; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020, Innsbruck, Austria; Division of Hygiene and Medical Microbiology, Medical University of Innsbru
Knabl L; Institute of Virology, Medical University of Innsbruck, Peter-Mayr-Straße 4b, 6020, Innsbruck, Austria.
Huber S; Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraße 41, 6020, Innsbruck, Austria.
Orth-Höller D; Division of Hygiene and Medical Microbiology, Medical University of Innsbruck, Schöpfstraße 41, 6020, Innsbruck, Austria.
Gust R; Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI - Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB - Centrum for Chemistry and Biomedicine, Innrain 80-82, 6020, Innsbruck, Austria. Electronic address: ronald.gust@uibk.ac.at.

Eur J Med Chem ; 209: 112907, 2021 Jan 01.

Article em En | MEDLINE | ID: mdl-33069056

Assuntos

Antibacterianos/química; Complexos de Coordenação/química; Etilenodiaminas/química; Compostos Férricos/química; Salicilatos/química; Antibacterianos/farmacologia; Ciprofloxacina/química; Complexos de Coordenação/farmacologia; Resistência Microbiana a Medicamentos; Ferroptose/efeitos dos fármacos; Bactérias Gram-Negativas; Humanos; Ligantes; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Testes de Sensibilidade Microbiana; Bases de Schiff/química; Relação Estrutura-Atividade; Tetraciclina/química

Palavras-chave

Antibacterial activity; Ferroptosis; MRSA; Metal complexes; Staphylococcus aureus; Time-kill kinetics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Compostos Férricos / Salicilatos / Etilenodiaminas / Complexos de Coordenação / Antibacterianos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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