Copper-64 labeled nanoparticles for positron emission tomography imaging: a review of the recent literature.
Q J Nucl Med Mol Imaging
; 64(4): 346-355, 2020 Dec.
Article
em En
| MEDLINE
| ID: mdl-33073558
ABSTRACT
INTRODUCTION:
Nuclear medicine plays a crucial role for personalized therapy, mainly in oncology. Chemotherapy and radiotherapy present some disadvantages and research is shifting toward nanotechnology with significant improvements in therapy and diagnosis of several cancers. Indeed, nanoparticles can be tagged with different radioisotopes for single photon emission computed tomography (SPECT) and positron emission tomography (PET) imaging and for therapy. This review describes the current state of the art of 64Copper-labeled nanoparticles for PET imaging of cancer. EVIDENCE ACQUISITION We performed a systematic analysis of literature using the terms "64CuClSYNTHESIS:
Amongst the 116 articles retrieved, 88 were excluded because reviews, or not in English, or only in-vitro studies or meeting presentations. We considered only 28 original papers. The most used nanoparticles are liposomes and they are mainly used in breast cancer although other animal models of cancer have been also investigated.CONCLUSIONS:
The results showed that nanoparticles can be considered a promising radiopharmaceutical for PET imaging of different type of cancer.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
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Radioisótopos de Cobre
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Compostos Radiofarmacêuticos
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Nanopartículas Metálicas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article