Intraocular pressure-lowering effects of ripasudil, a rho-kinase inhibitor, and selective laser trabeculoplasty as adjuvant therapy in patients with uncontrolled glaucoma.
Int Ophthalmol
; 41(2): 605-611, 2021 Feb.
Article
em En
| MEDLINE
| ID: mdl-33079310
ABSTRACT
OBJECTIVES:
To compare the intraocular pressure (IOP)-lowering effects of ripasudil, a rho-kinase inhibitor, and selective laser trabeculoplasty (SLT) as adjuvant therapy in Japanese glaucoma patients and to identify the factors associated with treatment success.METHODS:
We performed a retrospective medical chart review of patients with glaucoma who received ripasudil or SLT as an adjuvant therapy. We collected data on 65 eyes (65 patients) with primary open-angle glaucoma, normal-tension glaucoma, or exfoliation glaucoma with at least 12 months of follow-up. IOP and number of glaucoma medications at 0, 1, 3, 6, 9, and 12 months were compared between and within groups. A repeated-measures mixed model was used to perform statistical analysis. We also investigated factors associated with treatment success, which was defined as ≥ 20% reduction in IOP at all follow-up periods, using univariate and multivariate logistic regression analysis.RESULTS:
Significant IOP reduction was observed at all time-points after treatment in the ripasudil group (n = 33) and in the SLT group (n = 32), with no statistically significant difference between the groups before or after treatment. Patients in the SLT group used more anti-glaucoma medications before treatment, but fewer during follow-up, than those in the ripasudil group. Regardless of treatment, higher baseline IOP was associated with treatment success [crude odds ratio 1.21 (95% confidence interval 1.06-1.38), adjusted odds ratio 1.37 (95% confidence interval 1.06-1.77)].CONCLUSIONS:
Adjuvant SLT or ripasudil in patients with inadequately controlled glaucoma both reduced IOP to a similar degree, but SLT contributed to reducing the number of medications used.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Trabeculectomia
/
Glaucoma
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Glaucoma de Ângulo Aberto
/
Terapia a Laser
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article