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Complete inhibition of ABCB1 and ABCG2 at the blood-brain barrier by co-infusion of erlotinib and tariquidar to improve brain delivery of the model ABCB1/ABCG2 substrate [11C]erlotinib.
Tournier, Nicolas; Goutal, Sebastien; Mairinger, Severin; Hernández-Lozano, Irene; Filip, Thomas; Sauberer, Michael; Caillé, Fabien; Breuil, Louise; Stanek, Johann; Freeman, Anna F; Novarino, Gaia; Truillet, Charles; Wanek, Thomas; Langer, Oliver.
Afiliação
  • Tournier N; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Université Paris-Saclay, CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Orsay, France.
  • Goutal S; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Université Paris-Saclay, CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Orsay, France.
  • Mairinger S; MIRCen, CEA/IBFJ/DRF-JACOB/LMN, UMR CEA CNRS 9199-Université Paris Saclay, Fontenay-aux-Roses, France.
  • Hernández-Lozano I; Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
  • Filip T; Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria.
  • Sauberer M; Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
  • Caillé F; Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
  • Breuil L; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Université Paris-Saclay, CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Orsay, France.
  • Stanek J; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Université Paris-Saclay, CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Orsay, France.
  • Freeman AF; Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
  • Novarino G; Institute of Science and Technology (IST) Austria, Klosterneuburg, Austria.
  • Truillet C; Institute of Science and Technology (IST) Austria, Klosterneuburg, Austria.
  • Wanek T; Laboratoire d'Imagerie Biomédicale Multimodale (BioMaps), Université Paris-Saclay, CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Orsay, France.
  • Langer O; Preclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
J Cereb Blood Flow Metab ; 41(7): 1634-1646, 2021 07.
Article em En | MEDLINE | ID: mdl-33081568
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Encéfalo / Radioisótopos de Carbono / Barreira Hematoencefálica / Cloridrato de Erlotinib / Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP / Proteínas de Neoplasias Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quinolinas / Encéfalo / Radioisótopos de Carbono / Barreira Hematoencefálica / Cloridrato de Erlotinib / Membro 2 da Subfamília G de Transportadores de Cassetes de Ligação de ATP / Proteínas de Neoplasias Idioma: En Ano de publicação: 2021 Tipo de documento: Article