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In vitro biotransformation and evaluation of potential transformation products of chlorinated paraffins by high resolution accurate mass spectrometry.
He, Chang; van Mourik, Louise; Tang, Shaoyu; Thai, Phong; Wang, Xianyu; Brandsma, Sicco H; Leonards, Pim E G; Thomas, Kevin V; Mueller, Jochen F.
Afiliação
  • He C; Queensland Alliance for Environmental Health Science (QAEHS), The University of Queensland, 4102 Brisbane, Australia. Electronic address: c.he@uq.edu.au.
  • van Mourik L; Department of Environment and Health, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands.
  • Tang S; Research Center for Eco-environmental Engineering, Dongguan University of Technology, 511700 Dongguan, China.
  • Thai P; Queensland Alliance for Environmental Health Science (QAEHS), The University of Queensland, 4102 Brisbane, Australia.
  • Wang X; Queensland Alliance for Environmental Health Science (QAEHS), The University of Queensland, 4102 Brisbane, Australia.
  • Brandsma SH; Department of Environment and Health, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands.
  • Leonards PEG; Department of Environment and Health, Vrije Universiteit, De Boelelaan 1087, 1081 HV Amsterdam, The Netherlands.
  • Thomas KV; Queensland Alliance for Environmental Health Science (QAEHS), The University of Queensland, 4102 Brisbane, Australia.
  • Mueller JF; Queensland Alliance for Environmental Health Science (QAEHS), The University of Queensland, 4102 Brisbane, Australia.
J Hazard Mater ; 405: 124245, 2021 03 05.
Article em En | MEDLINE | ID: mdl-33082018
Chlorinated paraffins (CPs) are high production chemicals, which leads to their ubiquitous presence in the environment. To date, few studies have measured CPs in humans and typically at relatively low concentrations, despite indications that exposure may be high compared to various persistent organic pollutants. The aim of this study is to investigate the in vitro biotransformation of CPs by human liver fractions. We determined the changes of the CP concentrations after the enzymatic transformation with human liver microsomes using a two-tiered in vitro approach. CP concentrations decreased with human liver microsomes, with the decreases of 33-94% after incubating with different groups of enzymes for 2 h. The profiles of CP rapidly shifted after the incubation with human liver microsomes. In addition, the concentrations of CPs and the biotransformation products were tentatively measured using high-resolution mass spectrometric analysis, including very short CP (carbon chain length <10), alcohols, ketones, and carboxylic acids. C‒C bond cleavage is a potential transformation pathway for CPs, and ketones are potential products of CP biotransformation, especially for long-chain CPs (C>17). The ketone products may be investigated as CP exposure biomarker in biomonitoring studies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Parafina / Hidrocarbonetos Clorados Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Parafina / Hidrocarbonetos Clorados Idioma: En Ano de publicação: 2021 Tipo de documento: Article