FUS contributes to mTOR-dependent inhibition of translation.

Sévigny, Myriam; Bourdeau Julien, Isabelle; Venkatasubramani, Janani Priya; Hui, Jeremy B; Dutchak, Paul A; Sephton, Chantelle F

Sévigny, Myriam; Bourdeau Julien, Isabelle; Venkatasubramani, Janani Priya; Hui, Jeremy B; Dutchak, Paul A; Sephton, Chantelle F.

Afiliação

Sévigny M; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Bourdeau Julien I; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Venkatasubramani JP; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Hui JB; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Dutchak PA; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada.
Sephton CF; Department of Psychiatry and Neuroscience, CERVO Brain Research Centre, Laval University, Quebec City, Quebec, Canada. Electronic address: chantelle.sephton.1@ulaval.ca.

J Biol Chem ; 295(52): 18459-18473, 2020 12 25.

Article em En | MEDLINE | ID: mdl-33082139

Assuntos

Esclerose Lateral Amiotrófica/patologia; Mutação; Polirribossomos/metabolismo; Proteína FUS de Ligação a RNA/metabolismo; Serina-Treonina Quinases TOR/metabolismo; Esclerose Lateral Amiotrófica/genética; Esclerose Lateral Amiotrófica/metabolismo; Citoplasma/metabolismo; Células HEK293; Humanos; Corpos de Inclusão; Polirribossomos/genética; Biossíntese de Proteínas; Proteína FUS de Ligação a RNA/genética; Serina-Treonina Quinases TOR/genética

Palavras-chave

RNA-binding protein; Torin1; amyotrophic lateral sclerosis (ALS) (Lou Gehrig disease); fragile X mental retardation (FMRP); frontotemporal degeneration (FTD); fused in sarcoma (FUS); mRNA translation; mTORC1; mTORC2; mammalian target of rapamycin (mTOR); neurodegeneration; polyribosome; protein synthesis; rapamycin; ribosome; translation regulation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polirribossomos / Proteína FUS de Ligação a RNA / Serina-Treonina Quinases TOR / Esclerose Lateral Amiotrófica / Mutação Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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