Artesunate inhibits Sjögren's syndrome-like autoimmune responses and BAFF-induced B cell hyperactivation via TRAF6-mediated NF-&#954;B signaling.

Zhan, Tianle; Wang, Baoli; Fu, Jiayao; Shao, Yanxiong; Ye, Lei; Shi, Huan; Zheng, Lingyan

Artesunate inhibits Sjögren's syndrome-like autoimmune responses and BAFF-induced B cell hyperactivation via TRAF6-mediated NF-κB signaling.

Zhan, Tianle; Wang, Baoli; Fu, Jiayao; Shao, Yanxiong; Ye, Lei; Shi, Huan; Zheng, Lingyan.

Afiliação

Zhan T; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Sto
Wang B; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Sto
Fu J; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Sto
Shao Y; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Sto
Ye L; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Sto
Shi H; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Sto
Zheng L; Department of Oral Surgery, Shanghai Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai, China; National Clinical Research Center of Oral Disease, Shanghai, China; Shanghai Key Laboratory of Stomatology & Shanghai Research Institute of Sto

Phytomedicine ; 80: 153381, 2021 Jan.

Article em En | MEDLINE | ID: mdl-33086170

Assuntos

Artesunato/farmacologia; Fator Ativador de Células B/farmacologia; Linfócitos B/efeitos dos fármacos; Fatores Imunológicos/farmacologia; Síndrome de Sjogren/imunologia; Animais; Autoanticorpos/metabolismo; Autoimunidade/efeitos dos fármacos; Fator Ativador de Células B/metabolismo; Linfócitos B/imunologia; Linfócitos B/metabolismo; Linfócitos B/patologia; Linhagem Celular Tumoral; Modelos Animais de Doenças; Humanos; Peptídeos e Proteínas de Sinalização Intracelular/metabolismo; Linfócitos/efeitos dos fármacos; Camundongos Endogâmicos ICR; Camundongos Endogâmicos NOD; NF-kappa B/metabolismo; Glândulas Salivares/efeitos dos fármacos; Glândulas Salivares/metabolismo; Transdução de Sinais/efeitos dos fármacos; Síndrome de Sjogren/tratamento farmacológico; Síndrome de Sjogren/patologia

Palavras-chave

Artesunate; BAFF; NFκB; Sjögren's syndrome; TRAF6; Ubiquitination

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos B / Síndrome de Sjogren / Fator Ativador de Células B / Artesunato / Fatores Imunológicos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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