Respiratory traits and coal workers' pneumoconiosis: Mendelian randomisation and association analysis.
Occup Environ Med
; 78(2): 137-141, 2021 02.
Article
em En
| MEDLINE
| ID: mdl-33097673
ABSTRACT
OBJECTIVES:
Susceptibility loci of idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease were also significantly associated with the predisposition of coal worker's pneumoconiosis (CWP) in recent studies. However, only a few genes and loci were targeted in previous studies.METHODS:
To systematically evaluate the genetic associations between CWP and other respiratory traits, we reviewed the reported genome-wide association study loci of five respiratory traits and then conducted a Mendelian randomisation study and a two-stage genetic association study.RESULTS:
Interestingly, we found that for each SD unit, higher lung function was associated with a 66% lower risk of CWP (OR=0.34, 95% CI 0.15 to 0.77, p=0.010) using conventional Mendelian randomisation analysis (inverse variance weighted method). Moreover, we found susceptibility loci of interstitial lung disease (rs2609255, OR=1.29, p=1.61×10-4) and lung function (rs4651005, OR=1.39, p=1.62×10-3; rs985256, OR=0.73, p=8.24×10-4 and rs6539952, OR=1.28, p=4.32×10-4) were also significantly associated with the risk of CWP. Functional annotation showed these variants were significantly associated with the expression of FAM13A (rs2609255, p=7.4 ×10-4), ANGPTL1 (rs4651005, p=5.4 ×10-7), SPATS2L (rs985256, p=1.1 ×10-5) and RP11-463O9.9 (rs6539952, p=7.1 ×10-6) in normal lung tissues, which were related to autophagy pathway simultaneously according to enrichment analysis.CONCLUSIONS:
These results provided a deeper understanding of the genetic predisposition basis of CWP.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
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Antracose
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Estudo de Associação Genômica Ampla
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article