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MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk.
Surakka, Ida; Fritsche, Lars G; Zhou, Wei; Backman, Joshua; Kosmicki, Jack A; Lu, Haocheng; Brumpton, Ben; Nielsen, Jonas B; Gabrielsen, Maiken E; Skogholt, Anne Heidi; Wolford, Brooke; Graham, Sarah E; Chen, Y Eugene; Lee, Seunggeun; Kang, Hyun Min; Langhammer, Arnulf; Forsmo, Siri; Åsvold, Bjørn O; Styrkarsdottir, Unnur; Holm, Hilma; Gudbjartsson, Daniel; Stefansson, Kari; Baras, Aris; Abecasis, Goncalo R; Hveem, Kristian; Willer, Cristen J.
Afiliação
  • Surakka I; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
  • Fritsche LG; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
  • Zhou W; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, 1415 Washington Heights, 1700 SPH I, Ann Arbor, MI, 48109, USA.
  • Backman J; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, 415 Main Street, Cambridge, MA, 02142, USA.
  • Kosmicki JA; Department of Computational Medicine and Bioinformatics, University of Michigan, Palmer Commons, 100 Washtenaw Avenue, Ann Arbor, MI, 48109, USA.
  • Lu H; Regeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
  • Brumpton B; Regeneron Genetics Center, 777 Old Saw Mill River Road, Tarrytown, NY, 10591, USA.
  • Nielsen JB; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
  • Gabrielsen ME; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.
  • Skogholt AH; MRC Integrative Epidemiology Unit, University of Bristol, Oakfield House, Oakfield Grove, Bristol, BS8 2BN, UK.
  • Wolford B; Clinic of Thoracic and Occupational Medicine, St. Olavs Hospital, Trondheim University Hospital, Prinsesse Kristinas gate 3, 7030, Trondheim, Norway.
  • Graham SE; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
  • Chen YE; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.
  • Lee S; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.
  • Kang HM; Department of Computational Medicine and Bioinformatics, University of Michigan, Palmer Commons, 100 Washtenaw Avenue, Ann Arbor, MI, 48109, USA.
  • Langhammer A; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
  • Forsmo S; Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI, 48109, USA.
  • Åsvold BO; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, 1415 Washington Heights, 1700 SPH I, Ann Arbor, MI, 48109, USA.
  • Styrkarsdottir U; Department of Biostatistics and Center for Statistical Genetics, University of Michigan School of Public Health, 1415 Washington Heights, 1700 SPH I, Ann Arbor, MI, 48109, USA.
  • Holm H; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Postboks 8905, N-7491, Levanger, Norway.
  • Gudbjartsson D; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Postboks 8905, N-7491, Levanger, Norway.
  • Stefansson K; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, NO-7491, Trondheim, Norway.
  • Baras A; HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology, Postboks 8905, N-7491, Levanger, Norway.
  • Abecasis GR; deCODE genetics/Amgen, Inc., Sturlugata 8, 101, Reykjavik, Iceland.
  • Hveem K; deCODE genetics/Amgen, Inc., Sturlugata 8, 101, Reykjavik, Iceland.
  • Willer CJ; deCODE genetics/Amgen, Inc., Sturlugata 8, 101, Reykjavik, Iceland.
Nat Commun ; 11(1): 4093, 2020 10 23.
Article em En | MEDLINE | ID: mdl-33097703
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Glicoproteínas / Densidade Óssea / Proteínas da Matriz Extracelular / Predisposição Genética para Doença / Fraturas Ósseas / Estudos de Associação Genética Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Glicoproteínas / Densidade Óssea / Proteínas da Matriz Extracelular / Predisposição Genética para Doença / Fraturas Ósseas / Estudos de Associação Genética Idioma: En Ano de publicação: 2020 Tipo de documento: Article