A new role for histone demethylases in the maintenance of plant genome integrity.
Elife
; 92020 10 27.
Article
em En
| MEDLINE
| ID: mdl-33107825
ABSTRACT
Histone modifications deposited by the Polycomb repressive complex 2 (PRC2) play a critical role in the control of growth, development, and adaptation to environmental fluctuations of most multicellular eukaryotes. The catalytic activity of PRC2 is counteracted by Jumonji-type (JMJ) histone demethylases, which shapes the genomic distribution of H3K27me3. Here, we show that two JMJ histone demethylases in Arabidopsis, EARLY FLOWERING 6 (ELF6) and RELATIVE OF EARLY FLOWERING 6 (REF6), play distinct roles in H3K27me3 and H3K27me1 homeostasis. We show that failure to reset these chromatin marks during sexual reproduction results in the transgenerational inheritance of histone marks, which cause a loss of DNA methylation at heterochromatic loci and transposon activation. Thus, Jumonji-type histone demethylases play a dual role in plants by helping to maintain transcriptional states through development and safeguard genome integrity during sexual reproduction.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
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Arabidopsis
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Genoma de Planta
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Proteínas de Arabidopsis
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Histona Desmetilases com o Domínio Jumonji
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article