Viruses for Landscape-Scale Therapy: Biological Control of Rabbits in Australia.
Methods Mol Biol
; 2225: 1-23, 2021.
Article
em En
| MEDLINE
| ID: mdl-33108654
ABSTRACT
Viral diseases, whether of animals or humans, are normally considered as problems to be managed. However, in Australia, two viruses have been used as landscape-scale therapeutics to control European rabbits (Oryctolagus cuniculus), the preeminent invasive vertebrate pest species. Rabbits have caused major environmental and agricultural losses and contributed to extinction of native species. It was not until the introduction of Myxoma virus that effective control of this pest was obtained at a continental scale. Subsequent coevolution of rabbit and virus saw a gradual reduction in the effectiveness of biological control that was partially ameliorated by the introduction of the European rabbit flea to act as an additional vector for the virus. In 1995, a completely different virus, Rabbit hemorrhagic disease virus (RHDV), escaped from testing and spread through the Australian rabbit population and again significantly reduced rabbit numbers and environmental impacts. The evolutionary pressures on this virus appear to be producing quite different outcomes to those that occurred with myxoma virus and the emergence and invasion of a novel genotype of RHDV in 2014 have further augmented control. Molecular studies on myxoma virus have demonstrated multiple proteins that manipulate the host innate and adaptive immune response; however the molecular basis of virus attenuation and reversion to virulence are not yet understood.
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Base de dados:
MEDLINE
Assunto principal:
Reprodução
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Vírus da Doença Hemorrágica de Coelhos
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Infecções por Caliciviridae
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Agentes de Controle Biológico
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Myxoma virus
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Mixomatose Infecciosa
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article