In vivo PET imaging of neuroinflammation in familial frontotemporal dementia.
J Neurol Neurosurg Psychiatry
; 92(3): 319-322, 2021 03.
Article
em En
| MEDLINE
| ID: mdl-33122395
ABSTRACT
INTRODUCTION:
We report in vivo patterns of neuroinflammation and abnormal protein aggregation in seven cases of familial frontotemporal dementia (FTD) with mutations in MAPT, GRN and C9orf72 genes.METHODS:
Using positron emission tomography (PET), we explored the association of the distribution of activated microglia, as measured by the radioligand [11C]PK11195, and the regional distribution of tau or TDP-43 pathology, indexed using the radioligand [18F]AV-1451. The familial FTD PET data were compared with healthy controls.RESULTS:
Patients with familial FTD across all mutation groups showed increased [11C]PK11195 binding predominantly in frontotemporal regions, with additional regions showing abnormalities in individuals. Patients with MAPT mutations had a consistent distribution of [18F]AV-1451 binding across the brain, with heterogeneous distributions among carriers of GRN and C9orf72 mutations.DISCUSSION:
This case series suggests that neuroinflammation is part of the pathophysiology of familial FTD, warranting further consideration of immunomodulatory therapies for disease modification and prevention.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Demência Frontotemporal
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article