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Quantification of titanium dioxide nanoparticles in human urine by single-particle ICP-MS.
Salou, Samantha; Larivière, Dominic; Cirtiu, Ciprian-Mihai; Fleury, Normand.
Afiliação
  • Salou S; Chemistry Department, Université Laval, 1045 Ave de la Médecine, Quebec, QC, G1V 0A6, Canada.
  • Larivière D; Institut National de Santé Publique du Québec, Centre de Toxicologie du Québec, 945 Avenue Wolfe, Québec, QC, G1V 5B3, Canada.
  • Cirtiu CM; Chemistry Department, Université Laval, 1045 Ave de la Médecine, Quebec, QC, G1V 0A6, Canada. dominic.lariviere@chm.ulaval.ca.
  • Fleury N; Institut National de Santé Publique du Québec, Centre de Toxicologie du Québec, 945 Avenue Wolfe, Québec, QC, G1V 5B3, Canada. ciprian-mihai.cirtiu@inspq.qc.ca.
Anal Bioanal Chem ; 413(1): 171-181, 2021 Jan.
Article em En | MEDLINE | ID: mdl-33123763
ABSTRACT
The increasing use of titanium dioxide nanoparticles in daily use consumer products such as cosmetics, personal care products, food additives, and even medicine has led to growing concerns regarding human safety. It would be ideal to track exposure to this emerging nanopollutant, for example through bioassays, however, so far nanoparticle assessment in biological matrices such as urine remains challenging. The lack of data is mainly due to the limitations of the current metrology, but also to the low expected concentration in human samples. In this study, a quantification method for titanium dioxide nanoparticles in urine has been developed and validated following the ISO/CEI 170252017 guidelines. The detection limit for titanium dioxide nanoparticle mass concentration by single-particle inductively coupled plasma mass spectrometry (SP-ICP-MS) was 0.05 ng mL-1. The particle size limit was determined using three different approaches, with the highest calculated limit value approaching 50 nm. Repeatability and reproducibility of 14% and 18% respectively were achieved for particle mass concentration, and 6% for both parameters for particle size determination. Method trueness and recovery were 98% and 84%, respectively.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Titânio / Nanopartículas Metálicas Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Titânio / Nanopartículas Metálicas Idioma: En Ano de publicação: 2021 Tipo de documento: Article