Leptin receptor stimulation in late pregnant mouse uterine tissue inhibits spontaneous contractions by increasing NO and cGMP.

Srinivasan, G; Parida, Subhashree; Pavithra, S; Panigrahi, Manjit; Sahoo, Monalisa; Singh, Thakur Uttam; Madhu, C L; Manickam, Kesavan; Shyamkumar, T S; Kumar, Dinesh; Mishra, Santosh K

Srinivasan, G; Parida, Subhashree; Pavithra, S; Panigrahi, Manjit; Sahoo, Monalisa; Singh, Thakur Uttam; Madhu, C L; Manickam, Kesavan; Shyamkumar, T S; Kumar, Dinesh; Mishra, Santosh K.

Afiliação

Srinivasan G; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Parida S; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India. Electronic address: subhaparida1210@gmail.com.
Pavithra S; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Panigrahi M; Division of Animal Genetics and Breeding, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Sahoo M; Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Singh TU; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Madhu CL; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Manickam K; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Shyamkumar TS; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Kumar D; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.
Mishra SK; Division of Pharmacology and Toxicology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly, Uttar Pradesh 243122, India.

Cytokine ; 137: 155341, 2021 01.

Article em En | MEDLINE | ID: mdl-33128919

Assuntos

GMP Cíclico/metabolismo; Leptina/farmacologia; Óxido Nítrico/metabolismo; Receptores para Leptina/metabolismo; Contração Uterina/efeitos dos fármacos; Útero/efeitos dos fármacos; Albuterol/farmacologia; Animais; Relação Dose-Resposta a Droga; Etanolaminas/farmacologia; Feminino; Regulação da Expressão Gênica/efeitos dos fármacos; Sistema de Sinalização das MAP Quinases/efeitos dos fármacos; Masculino; Camundongos; Gravidez; Isoformas de Proteínas/agonistas; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Receptores para Leptina/agonistas; Receptores para Leptina/genética; Útero/metabolismo; Útero/fisiologia

Palavras-chave

ERK1/2; JAK2/3; Leptin; Leptin receptors; Nitric oxide; cGMP

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Contração Uterina / Útero / GMP Cíclico / Leptina / Receptores para Leptina / Óxido Nítrico Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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