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Evaluation of ultrahigh-resolution optical coherence tomography for basal cell carcinoma, seborrheic keratosis, and nevus.
Chen, Shufen; Xie, Fang; Hao, Tian; Xie, Jun; Wang, Xianghong; Chen, Si; Liu, Linbo; Li, Chengxin.
Afiliação
  • Chen S; School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore.
  • Xie F; School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China.
  • Hao T; Department of Dermatology, People's Liberation Army General Hospital, Beijing, China.
  • Xie J; Department of Dermatology, People's Liberation Army General Hospital, Beijing, China.
  • Wang X; School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore.
  • Chen S; School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore.
  • Liu L; School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore.
  • Li C; School of Electrical and Electronic Engineering, Nanyang Technological University, Singapore, Singapore.
Skin Res Technol ; 27(4): 479-485, 2021 Jul.
Article em En | MEDLINE | ID: mdl-33141994
ABSTRACT

BACKGROUND:

Basal cell carcinoma, seborrheic keratosis, and nevus are common skin conditions. Though most of the skin diseases can be distinguished from each other by physician's naked eyes, the diagnostic accuracy is not 100%. The accurate diagnosis and assessment of three diseases make a big difference on the clinical management. Nowadays, biopsy is still the gold standard for diagnosis even it is invasive, time-consuming, and painful. Ultrahigh-resolution optical coherence tomography is an emerging technology that can produce in situ, cellular-resolution, real-time, continuous, 3D images in a noninvasive way. MATERIALS AND

METHODS:

In our study, four basal cell carcinoma patients, five seborrheic keratosis patients, and 10 nevus patients who were diagnosed by histology were studied by ultrahigh-resolution optical coherence tomography after visual examination by experienced dermatologists. Cellular contrast was utilized to clearly identify the features of the three skin diseases.

RESULTS:

The features including such as hyperkeratosis (horn pseudocysts), papillomatosis, intraepidermal nests, elongated, and expanded rete ridge can be visualized in seborrheic keratosis. Tumor nodular, mucin surrounding with tumor (retraction space in histopathology), tumor subtype, and necrosis were featured in basal cell carcinoma. Pigment was characterized in epidermis and dermis. The comparison of ultrahigh-resolution optical coherence tomography images reveals a strong correlation with histological images.

CONCLUSION:

Ultrahigh-resolution optical coherence tomography can complement existing diagnostic techniques for investigating seborrheic keratosis, basal cell carcinoma and nevus, and show enormous potential in vivo applications for the three skin diseases in the future.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma Basocelular / Ceratose Seborreica / Nevo Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Cutâneas / Carcinoma Basocelular / Ceratose Seborreica / Nevo Idioma: En Ano de publicação: 2021 Tipo de documento: Article