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Structure-Based Drug Design of Bisubstrate Inhibitors of Phenylethanolamine N-Methyltransferase Possessing Low Nanomolar Affinity at Both Substrate Binding Domains1.
Lu, Jian; Bart, Aaron G; Wu, Qian; Criscione, Kevin R; McLeish, Michael J; Scott, Emily E; Grunewald, Gary L.
Afiliação
  • Lu J; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
  • Bart AG; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
  • Wu Q; Department of Chemistry and Chemical Biology, Purdue School of Science, IUPUI, Indianapolis, Indiana 46202, United States.
  • Criscione KR; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
  • McLeish MJ; Department of Chemistry and Chemical Biology, Purdue School of Science, IUPUI, Indianapolis, Indiana 46202, United States.
  • Scott EE; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
  • Grunewald GL; Department of Medicinal Chemistry, University of Kansas, Lawrence, Kansas 66045, United States.
J Med Chem ; 63(22): 13878-13898, 2020 11 25.
Article em En | MEDLINE | ID: mdl-33147410
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Feniletanolamina N-Metiltransferase / S-Adenosilmetionina / Desenho de Fármacos / Adenosina / Inibidores Enzimáticos / Isoquinolinas Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Feniletanolamina N-Metiltransferase / S-Adenosilmetionina / Desenho de Fármacos / Adenosina / Inibidores Enzimáticos / Isoquinolinas Idioma: En Ano de publicação: 2020 Tipo de documento: Article