Diterpenoids from Callicarpa rubella and their in vitro anti-NLRP3 inflammasome activity.
Fitoterapia
; 147: 104774, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-33152461
ABSTRACT
Nine new diterpenoids, Rubellacrns A - I (1-9), including five isopimaranes (1-4, 9), four pimaranes (5-8), together with five known isopimarane analogues (10-14), were isolated from Callicarpa rubella. The structures of these compounds were unambiguously established by HR-ESIMS and NMR spectroscopic data, the absolute configurations of compounds 5 and 9 were determined by ECD. All the isolated compounds were tested for their anti-inflammatory effects and compounds 2 and 11-14 showed NLRP3-inflammasome inhibitory activity with IC50 values ranging from 7.02 to 14.38 µM.
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MEDLINE
Assunto principal:
Callicarpa
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Diterpenos
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Inflamassomos
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Proteína 3 que Contém Domínio de Pirina da Família NLR
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article