Activation of ß2 adrenergic receptor signaling modulates inflammation: a target limiting the progression of kidney diseases.
Arch Pharm Res
; 44(1): 49-62, 2021 Jan.
Article
em En
| MEDLINE
| ID: mdl-33155167
ABSTRACT
Beta 2 adrenergic receptor (ß2-AR)-agonists, widely used as bronchodilators, have demonstrated wide-spectrum anti-inflammatory properties in both immune and non-immune cells in various tissues. Their anti-inflammatory properties are mediated primarily, but not exclusively, via activation of the canonical ß2-AR signaling pathway (ß2-AR/cAMP/PKA). As non-canonical ß2-AR signaling also occurs, several inconsistent findings on the anti-inflammatory effect of ß2-agonists are notably present. Increasing amounts of evidence have unveiled the alternative mechanisms of the ß2-AR agonists in protecting the tissues against injuries, i.e., by augmenting mitochondria biogenesis and SIRT1 activity, and by attenuating fibrotic signaling. This review mainly covers the basic mechanisms of the anti-inflammatory effects of ß2-AR activation along with its limitations. Specifically, we summarized the role of ß2-AR signaling in regulating kidney function and in mediating the progression of acute and chronic kidney diseases. Given their versatile protective effects, ß2-agonists can be a promising avenue in the treatment of kidney diseases.
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MEDLINE
Assunto principal:
Receptores Adrenérgicos beta 2
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Agonistas de Receptores Adrenérgicos beta 2
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Inflamação
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Anti-Inflamatórios
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article