Fasudil attenuates glial cell-mediated neuroinflammation via ERK1/2 and AKT signaling pathways after optic nerve crush.

Huang, Wei; Lan, Qianqian; Jiang, Li; Yan, Wenya; Tang, Fen; Shen, Chaolan; Huang, Hui; Zhong, Haibin; Lv, Jian; Zeng, Siming; Li, Min; Mo, Zhongxiang; Hu, Bing; Liang, Ning; Chen, Qi; Zhang, Mingyuan; Xu, Fan; Cui, Ling

Huang, Wei; Lan, Qianqian; Jiang, Li; Yan, Wenya; Tang, Fen; Shen, Chaolan; Huang, Hui; Zhong, Haibin; Lv, Jian; Zeng, Siming; Li, Min; Mo, Zhongxiang; Hu, Bing; Liang, Ning; Chen, Qi; Zhang, Mingyuan; Xu, Fan; Cui, Ling.

Afiliação

Huang W; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Lan Q; Guangxi Medical University, Nanning, 530021, China.
Jiang L; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Yan W; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Tang F; Guangzhou Medical University, Guangzhou, 511436, China.
Shen C; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Huang H; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Zhong H; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Lv J; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Zeng S; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Li M; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Mo Z; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Hu B; Laboratory Animal Center, Guangxi Medical University, Nanning, 530021, China.
Liang N; Laboratory Animal Center, Guangxi Medical University, Nanning, 530021, China.
Chen Q; Laboratory Animal Center, Guangxi Medical University, Nanning, 530021, China.
Zhang M; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China.
Xu F; Laboratory Animal Center, Guangxi Medical University, Nanning, 530021, China.
Cui L; Department of Ophthalmology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, China. oph_fan@163.com.

Mol Biol Rep ; 47(11): 8963-8973, 2020 Nov.

Article em En | MEDLINE | ID: mdl-33161529

Assuntos

1-(5-Isoquinolinasulfonil)-2-Metilpiperazina/análogos & derivados; Inflamação/prevenção & controle; Neuroglia/metabolismo; Nervo Óptico/metabolismo; Proteínas Quinases/metabolismo; Transdução de Sinais/efeitos dos fármacos; 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina/farmacologia; Animais; Apoptose/efeitos dos fármacos; Citocinas/genética; Citocinas/metabolismo; MAP Quinases Reguladas por Sinal Extracelular/metabolismo; Expressão Gênica/efeitos dos fármacos; Inflamação/genética; Inflamação/metabolismo; Masculino; Compressão Nervosa; Neuroglia/citologia; Fármacos Neuroprotetores/farmacologia; Nervo Óptico/patologia; Traumatismos do Nervo Óptico/metabolismo; Traumatismos do Nervo Óptico/fisiopatologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Ratos Sprague-Dawley; Células Ganglionares da Retina/citologia; Células Ganglionares da Retina/efeitos dos fármacos; Células Ganglionares da Retina/metabolismo

Palavras-chave

Fasudil; Neuroinflammation; Optic nerve crush; Retinal ganglion cells; p-AKT; p-ERK1/2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Nervo Óptico / Proteínas Quinases / Transdução de Sinais / Neuroglia / 1-(5-Isoquinolinasulfonil)-2-Metilpiperazina / Inflamação Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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