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The Influence of Tumor Microenvironment on Immune Escape of Melanoma.
Simiczyjew, Aleksandra; Dratkiewicz, Ewelina; Mazurkiewicz, Justyna; Zietek, Marcin; Matkowski, Rafal; Nowak, Dorota.
Afiliação
  • Simiczyjew A; Department of Cell Pathology, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland.
  • Dratkiewicz E; Department of Cell Pathology, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland.
  • Mazurkiewicz J; Department of Cell Pathology, Faculty of Biotechnology, University of Wroclaw, Joliot-Curie 14a, 50-383 Wroclaw, Poland.
  • Zietek M; Department of Oncology and Division of Surgical Oncology, Wroclaw Medical University, Plac Hirszfelda 12, 53-413 Wroclaw, Poland.
  • Matkowski R; Wroclaw Comprehensive Cancer Center, Plac Hirszfelda 12, 53-413 Wroclaw, Poland.
  • Nowak D; Department of Oncology and Division of Surgical Oncology, Wroclaw Medical University, Plac Hirszfelda 12, 53-413 Wroclaw, Poland.
Int J Mol Sci ; 21(21)2020 Nov 07.
Article em En | MEDLINE | ID: mdl-33171792
ABSTRACT
The low efficiency of currently-used anti-cancer therapies poses a serious challenge, especially in the case of malignant melanoma, a cancer characterized by elevated invasiveness and relatively high mortality rate. The role of the tumor microenvironment in the progression of melanoma and its acquisition of resistance to treatment seems to be the main focus of recent studies. One of the factors that, in normal conditions, aids the organism in its fight against the cancer and, following the malignant transformation, adapts to facilitate the development of the tumor is the immune system. A variety of cell types, i.e., T and B lymphocytes, macrophages, and dendritic and natural killer cells, as well as neutrophils, support the growth and invasiveness of melanoma cells, utilizing a plethora of mechanisms, including secretion of pro-inflammatory molecules, induction of inhibitory receptors expression, or depletion of essential nutrients. This review provides a comprehensive summary of the processes regulated by tumor-associated cells that promote the immune escape of melanoma cells. The described mechanisms offer potential new targets for anti-cancer treatment and should be further studied to improve currently-employed therapies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Evasão Tumoral / Microambiente Tumoral / Melanoma Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Evasão Tumoral / Microambiente Tumoral / Melanoma Idioma: En Ano de publicação: 2020 Tipo de documento: Article