Isoharringtonine Induces Apoptosis of Non-Small Cell Lung Cancer Cells in Tumorspheroids via the Intrinsic Pathway.

Lee, Ji Hae; Park, So-Young; Hwang, Wonbin; Sung, Jee Young; Cho, Myoung-Lae; Shim, Jaegal; Kim, Yong-Nyun; Yoon, Kyungsil

Lee, Ji Hae; Park, So-Young; Hwang, Wonbin; Sung, Jee Young; Cho, Myoung-Lae; Shim, Jaegal; Kim, Yong-Nyun; Yoon, Kyungsil.

Afiliação

Lee JH; Division of Translational Research, National Cancer Center, Goyang 10408, Korea.
Park SY; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Korea.
Hwang W; Division of Translational Research, National Cancer Center, Goyang 10408, Korea.
Sung JY; Division of Translational Research, National Cancer Center, Goyang 10408, Korea.
Cho ML; Division of Translational Research, National Cancer Center, Goyang 10408, Korea.
Shim J; National Institute for Korean Medicine Development, Gyeongsan 38540, Korea.
Kim YN; Division of Translational Research, National Cancer Center, Goyang 10408, Korea.
Yoon K; Division of Translational Research, National Cancer Center, Goyang 10408, Korea.

Biomolecules ; 10(11)2020 11 06.

Article em En | MEDLINE | ID: mdl-33172112

Assuntos

Apoptose/efeitos dos fármacos; Carcinogênese/efeitos dos fármacos; Carcinoma Pulmonar de Células não Pequenas/patologia; Harringtoninas/farmacologia; Neoplasias Pulmonares/patologia; Animais; Linhagem Celular Tumoral; Proliferação de Células/efeitos dos fármacos; Camundongos; Transdução de Sinais/efeitos dos fármacos; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

NR4A1; NSCLC; apoptosis; isoharringtonine; tumorspheroids

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Carcinoma Pulmonar de Células não Pequenas / Carcinogênese / Harringtoninas / Neoplasias Pulmonares Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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