In vitro selection generates RNA aptamer that antagonizes PCSK9-LDLR interaction and recovers cellular LDL uptake.

Ando, Takehiro; Yamamoto, Mizuki; Yokoyama, Takumi; Horiuchi, Daisuke; Kawakami, Takashi

In vitro selection generates RNA aptamer that antagonizes PCSK9-LDLR interaction and recovers cellular LDL uptake.

Ando, Takehiro; Yamamoto, Mizuki; Yokoyama, Takumi; Horiuchi, Daisuke; Kawakami, Takashi.

Afiliação

Ando T; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi 400-8510, Japan.
Yamamoto M; Department of Integrated Applied Life Science, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi 400-8510, Japan.
Yokoyama T; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi 400-8510, Japan.
Horiuchi D; Department of Life and Environmental Sciences, Integrated Graduate School of Medicine, Engineering, and Agricultural Sciences, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi 400-8510, Japan.
Kawakami T; Faculty of Life and Environmental Sciences, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, 4-4-37 Takeda, Kofu, Yamanashi 400-8510, Japan; Japan Science and Technology Agency (JST), PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama 332-0012, Japan. Electronic address: tkawakami@yama

J Biosci Bioeng ; 131(3): 326-332, 2021 Mar.

Article em En | MEDLINE | ID: mdl-33177004

Assuntos

Aptâmeros de Nucleotídeos/metabolismo; Pró-Proteína Convertase 9/metabolismo; Receptores de LDL/metabolismo; Células Hep G2; Humanos; Inibidores de PCSK9; Ligação Proteica; Receptores de LDL/genética

Palavras-chave

Hypercholesterolemia; Low-density lipoprotein cholesterol; Proprotein convertase subtilisin/kexin type 9; RNA aptamer; Systematic evolution of ligands by exponential enrichment

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de LDL / Aptâmeros de Nucleotídeos / Pró-Proteína Convertase 9 Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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