The auxin-inducible degron 2 technology provides sharp degradation control in yeast, mammalian cells, and mice.

Yesbolatova, Aisha; Saito, Yuichiro; Kitamoto, Naomi; Makino-Itou, Hatsune; Ajima, Rieko; Nakano, Risako; Nakaoka, Hirofumi; Fukui, Kosuke; Gamo, Kanae; Tominari, Yusuke; Takeuchi, Haruki; Saga, Yumiko; Hayashi, Ken-Ichiro; Kanemaki, Masato T

Yesbolatova, Aisha; Saito, Yuichiro; Kitamoto, Naomi; Makino-Itou, Hatsune; Ajima, Rieko; Nakano, Risako; Nakaoka, Hirofumi; Fukui, Kosuke; Gamo, Kanae; Tominari, Yusuke; Takeuchi, Haruki; Saga, Yumiko; Hayashi, Ken-Ichiro; Kanemaki, Masato T.

Afiliação

Yesbolatova A; Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Yata 1111, Mishima, Shizuoka, 411-8540, Japan.
Saito Y; Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), Yata 1111, Mishima, Shizuoka, 411-8540, Japan.
Kitamoto N; Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Yata 1111, Mishima, Shizuoka, 411-8540, Japan.
Makino-Itou H; Department of Chromosome Science, National Institute of Genetics, Research Organization of Information and Systems (ROIS), Yata 1111, Mishima, Shizuoka, 411-8540, Japan.
Ajima R; FIMECS, Inc., Muraoka-Higashi 2-26-1, Fujisawa, Kanagawa, 251-0012, Japan.
Nakano R; Department of Gene Function and Phenomics, National Institute of Genetics, ROIS, Yata 1111, Mishima, Shizuoka, 411-8540, Japan.
Nakaoka H; Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), Yata 1111, Mishima, Shizuoka, 411-8540, Japan.
Fukui K; Department of Gene Function and Phenomics, National Institute of Genetics, ROIS, Yata 1111, Mishima, Shizuoka, 411-8540, Japan.
Gamo K; Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo, Tokyo, 113-0033, Japan.
Tominari Y; Department of Genetics, The Graduate University for Advanced Studies (SOKENDAI), Yata 1111, Mishima, Shizuoka, 411-8540, Japan.
Takeuchi H; Department of Genomics and Evolutionary Biology, National Institute of Genetics, ROIS, Yata 1111, Mishima, Shizuoka, 411-8540, Japan.
Saga Y; Department of Cancer Genome Research, Sasaki Institute, Sasaki Foundation, Kandasurugadai 2-2, Chiyoda-ku, Tokyo, 101-0062, Japan.
Hayashi KI; Department of Biochemistry, Okayama University of Science, Ridai-cho 1-1, Okayama, 700-0005, Japan.
Kanemaki MT; FIMECS, Inc., Muraoka-Higashi 2-26-1, Fujisawa, Kanagawa, 251-0012, Japan.

Nat Commun ; 11(1): 5701, 2020 11 11.

Article em En | MEDLINE | ID: mdl-33177522

Assuntos

Proteólise/efeitos dos fármacos; Proteômica/métodos; Proteínas Recombinantes de Fusão/metabolismo; Animais; Proteínas de Ciclo Celular/genética; Proteínas de Ciclo Celular/metabolismo; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Feminino; Células HCT116; Hipocampo/citologia; Humanos; Ácidos Indolacéticos/farmacologia; Masculino; Camundongos Endogâmicos BALB C; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Proteínas de Manutenção de Minicromossomo/genética; Proteínas de Manutenção de Minicromossomo/metabolismo; Mutação; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Proteínas Nucleares/genética; Proteínas Nucleares/metabolismo; Oryza/genética; Proteínas de Plantas/genética; Proteínas de Plantas/metabolismo; Proteínas Recombinantes de Fusão/genética; Proteínas de Saccharomyces cerevisiae/genética; Proteínas de Saccharomyces cerevisiae/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Recombinantes de Fusão / Proteômica / Proteólise Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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