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Designed nanomolar small-molecule inhibitors of Ena/VASP EVH1 interaction impair invasion and extravasation of breast cancer cells.
Barone, Matthias; Müller, Matthias; Chiha, Slim; Ren, Jiang; Albat, Dominik; Soicke, Arne; Dohmen, Stephan; Klein, Marco; Bruns, Judith; van Dinther, Maarten; Opitz, Robert; Lindemann, Peter; Beerbaum, Monika; Motzny, Kathrin; Roske, Yvette; Schmieder, Peter; Volkmer, Rudolf; Nazaré, Marc; Heinemann, Udo; Oschkinat, Hartmut; Ten Dijke, Peter; Schmalz, Hans-Günther; Kühne, Ronald.
Afiliação
  • Barone M; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Müller M; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Chiha S; Department of Chemistry, Universität zu Köln, 50939 Köln, Germany.
  • Ren J; Oncode Institute, Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 Leiden, The Netherlands.
  • Albat D; Department of Chemistry, Universität zu Köln, 50939 Köln, Germany.
  • Soicke A; Department of Chemistry, Universität zu Köln, 50939 Köln, Germany.
  • Dohmen S; Department of Chemistry, Universität zu Köln, 50939 Köln, Germany.
  • Klein M; Department of Chemistry, Universität zu Köln, 50939 Köln, Germany.
  • Bruns J; Department of Chemistry, Universität zu Köln, 50939 Köln, Germany.
  • van Dinther M; Oncode Institute, Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 Leiden, The Netherlands.
  • Opitz R; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Lindemann P; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Beerbaum M; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Motzny K; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Roske Y; Department of Macromolecular Structure and Interaction, Max-Delbrück-Centrum für Molekulare Medizin, 13125 Berlin, Germany.
  • Schmieder P; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Volkmer R; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Nazaré M; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Heinemann U; Department of Macromolecular Structure and Interaction, Max-Delbrück-Centrum für Molekulare Medizin, 13125 Berlin, Germany.
  • Oschkinat H; Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
  • Ten Dijke P; Department of Structural Biology, Leibniz-Forschungsinstitut für Molekulare Pharmakologie, 13125 Berlin, Germany.
  • Schmalz HG; Institute of Chemistry and Biochemistry, Freie Universität Berlin, 14195 Berlin, Germany.
  • Kühne R; Oncode Institute, Department of Cell and Chemical Biology, Leiden University Medical Center, 2333 Leiden, The Netherlands; kuehne@fmp-berlin.de p.ten_dijke@lumc.nl schmalz@uni-koeln.de.
Proc Natl Acad Sci U S A ; 117(47): 29684-29690, 2020 11 24.
Article em En | MEDLINE | ID: mdl-33184177
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Neoplasias da Mama / Moléculas de Adesão Celular / Proteínas de Ligação a DNA / Bibliotecas de Moléculas Pequenas / Domínios e Motivos de Interação entre Proteínas / Proteínas dos Microfilamentos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfoproteínas / Neoplasias da Mama / Moléculas de Adesão Celular / Proteínas de Ligação a DNA / Bibliotecas de Moléculas Pequenas / Domínios e Motivos de Interação entre Proteínas / Proteínas dos Microfilamentos Idioma: En Ano de publicação: 2020 Tipo de documento: Article