Interleukin-33 alleviates diabetic cardiomyopathy through regulation of endoplasmic reticulum stress and autophagy via insulin-like growth factor-binding protein 3.

Wu, Mao-Xiong; Wang, Shao-Hua; Xie, Yong; Chen, Zhi-Teng; Guo, Qi; Yuan, Wo-Liang; Guan, Chang; Xu, Cheng-Zhang; Huang, Yu-Na; Wang, Jing-Feng; Zhang, Hai-Feng; Chen, Yang-Xin

Wu, Mao-Xiong; Wang, Shao-Hua; Xie, Yong; Chen, Zhi-Teng; Guo, Qi; Yuan, Wo-Liang; Guan, Chang; Xu, Cheng-Zhang; Huang, Yu-Na; Wang, Jing-Feng; Zhang, Hai-Feng; Chen, Yang-Xin.

Afiliação

Wu MX; Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Wang SH; Laboratory of Cardiac Electrophysiology and Arrhythmia in Guangdong Province, Guangzhou, Guangdong, China.
Xie Y; Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Chen ZT; Laboratory of Cardiac Electrophysiology and Arrhythmia in Guangdong Province, Guangzhou, Guangdong, China.
Guo Q; Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yuan WL; Laboratory of Cardiac Electrophysiology and Arrhythmia in Guangdong Province, Guangzhou, Guangdong, China.
Guan C; Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Xu CZ; Laboratory of Cardiac Electrophysiology and Arrhythmia in Guangdong Province, Guangzhou, Guangdong, China.
Huang YN; Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Wang JF; Laboratory of Cardiac Electrophysiology and Arrhythmia in Guangdong Province, Guangzhou, Guangdong, China.
Zhang HF; Department of Cardiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
Chen YX; Laboratory of Cardiac Electrophysiology and Arrhythmia in Guangdong Province, Guangzhou, Guangdong, China.

J Cell Physiol ; 236(6): 4403-4419, 2021 06.

Article em En | MEDLINE | ID: mdl-33184863

Assuntos

Autofagia/efeitos dos fármacos; Diabetes Mellitus Tipo 2/tratamento farmacológico; Cardiomiopatias Diabéticas/prevenção & controle; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina/metabolismo; Interleucina-33/farmacologia; Miócitos Cardíacos/efeitos dos fármacos; Animais; Proteínas Reguladoras de Apoptose/metabolismo; Proteínas Relacionadas à Autofagia/metabolismo; Células Cultivadas; Diabetes Mellitus Tipo 2/complicações; Diabetes Mellitus Tipo 2/metabolismo; Diabetes Mellitus Tipo 2/patologia; Cardiomiopatias Diabéticas/etiologia; Cardiomiopatias Diabéticas/metabolismo; Cardiomiopatias Diabéticas/patologia; Modelos Animais de Doenças; Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina/genética; Masculino; Camundongos; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; Ácido Palmítico/toxicidade; Ratos Sprague-Dawley; Transdução de Sinais

Palavras-chave

autophagy; diabetic cardiomyopathy; endoplasmic reticulum stress; insulin-like growth factor-binding protein3; interleukin-33

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Proteína 3 de Ligação a Fator de Crescimento Semelhante à Insulina / Miócitos Cardíacos / Diabetes Mellitus Tipo 2 / Cardiomiopatias Diabéticas / Estresse do Retículo Endoplasmático / Interleucina-33 Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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