A small-sized benzothiazole-indolium fluorescent probe: the study of interaction specificity targeting c-MYC promoter G-quadruplex structures and live cell imaging.
Chem Commun (Camb)
; 56(95): 15016-15019, 2020 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-33185205
A small-sized c-MYC promoter G-quadruplex selective fluorescent BZT-Indolium binding ligand was demonstrated for the first time as a highly target-specific and photostable probe for in vitro staining and live cell imaging and it was found to be able to inhibit the amplification of the c-MYC G-rich sequence (G-quadruplex) and down-regulate oncogene c-MYC expression in human cancer cells (HeLa).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Proteínas de Ligação a DNA
/
Benzotiazóis
/
Corantes Fluorescentes
/
Indóis
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article