Your browser doesn't support javascript.
loading
Forkhead box O1-mediated ubiquitination suppresses RIG-I-mediated antiviral immune responses.
Ma, Zhenling; Zhang, Wenwen; Fan, Wenhui; Wu, Yaru; Zhang, Menghao; Xu, Jun; Li, Wenqing; Sun, Lei; Liu, Wenjun; Liu, Wei.
Afiliação
  • Ma Z; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
  • Zhang W; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
  • Fan W; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China.
  • Wu Y; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
  • Zhang M; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
  • Xu J; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
  • Li W; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China.
  • Sun L; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
  • Liu W; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.
  • Liu W; College of Life Sciences, Henan Agricultural University, Zhengzhou 450002, China. Electronic address: liuv0216@163.com.
Int Immunopharmacol ; 90: 107152, 2021 Jan.
Article em En | MEDLINE | ID: mdl-33187908
RNA virus infection activates the RIG-I-like Receptor (RLR) signaling pathway to produce type I interferons (IFNs), the key components of the antiviral immune response. Forkhead box O1 (FoxO1) is a host transcription factor that participates in multiple biological processes. In this study, FoxO1 was identified as a critical negative regulator of RIG-I-triggered signaling. FoxO1 promoted Sendai virus (SeV) replication and downregulated type I IFN production. Upon SeV infection, FoxO1 suppressed K63-linked ubiquitination of TRAF3 and the interaction between TRAF3 and TBK1, after which the production of type I IFNs via the interferon regulatory transcription factor 3 (IRF3) pathways was reduced. In addition, FoxO1 destabilized IRF3 by facilitating E3 ligase TRIM22- or TRIM21-mediated K48-linked ubiquitination of IRF3. Moreover, the inhibitory effect of FoxO1 was found to depend on its DNA binding domain (DBD). Thus, our findings highlight novel important roles of FoxO1 in controlling RLR-mediated antiviral innate immunity.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Vírus de RNA / Interferon Tipo I / Proteína DEAD-box 58 / Proteína Forkhead Box O1 / Imunidade Inata Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Vírus de RNA / Interferon Tipo I / Proteína DEAD-box 58 / Proteína Forkhead Box O1 / Imunidade Inata Idioma: En Ano de publicação: 2021 Tipo de documento: Article