Disease-associated acrolein: A possible diagnostic and therapeutic substrate for in vivo synthetic chemistry.
Bioorg Med Chem
; 28(24): 115831, 2020 12 15.
Article
em En
| MEDLINE
| ID: mdl-33199202
ABSTRACT
Acrolein, a highly reactive α,ß-unsaturated aldehyde, is a compound to which humans are exposed in many different situations and often causes various human diseases. This paper summarizes the reports over the past twenty-five years regarding disease-associated acrolein detected in clinical patients and the role acrolein plays in various diseases. In several diseases, it was found that the increased acrolein acts as a pathogenetic factor. Thus, we propose the utility of over-produced acrolein as a substrate for a promising therapeutic or diagnostic method applicable to a wide range of diseases based on an in vivo synthetic chemistry strategy.
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Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
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Acroleína
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Encefalopatias
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Doença de Alzheimer
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article