A Stochastic Petri Net-Based Model of the Involvement of Interleukin 18 in Atherosclerosis.
Int J Mol Sci
; 21(22)2020 Nov 13.
Article
em En
| MEDLINE
| ID: mdl-33202974
ABSTRACT
Interleukin 18 (IL-18) is a proinflammatory and proatherogenic cytokine with pleiotropic properties, which is involved in T and NK cell maturation and the synthesis of other inflammatory cytokines and cell adhesion molecules. It plays a significant role in orchestrating the cytokine cascade, accelerates atherosclerosis and influences plaque vulnerability. To investigate the influence of IL-18 cytokine on atherosclerosis development, a stochastic Petri net model was built and then analyzed. First, MCT-sets and t-clusters were generated, then knockout and simulation-based analysis was conducted. The application of systems approach that was used in this research enabled an in-depth analysis of the studied phenomenon. Our results gave us better insight into the studied phenomenon and allow revealing that activation of macrophages by the classical pathway and IL-18-MyD88 signaling axis is crucial for the modeled process.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Simulação por Computador
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Software
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Transdução de Sinais
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Interleucina-18
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Aterosclerose
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Modelos Cardiovasculares
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article