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How directed evolution reshapes the energy landscape in an enzyme to boost catalysis.
Otten, Renee; Pádua, Ricardo A P; Bunzel, H Adrian; Nguyen, Vy; Pitsawong, Warintra; Patterson, MacKenzie; Sui, Shuo; Perry, Sarah L; Cohen, Aina E; Hilvert, Donald; Kern, Dorothee.
Afiliação
  • Otten R; Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.
  • Pádua RAP; Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.
  • Bunzel HA; Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland.
  • Nguyen V; Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.
  • Pitsawong W; Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.
  • Patterson M; Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA.
  • Sui S; Department of Chemical Engineering, Institute of Applied Life Sciences, University of Massachusetts, Amherst, MA 01003, USA.
  • Perry SL; Department of Chemical Engineering, Institute of Applied Life Sciences, University of Massachusetts, Amherst, MA 01003, USA.
  • Cohen AE; Stanford Synchrotron Radiation Lightsource, Menlo Park, CA 94025, USA.
  • Hilvert D; Laboratory of Organic Chemistry, ETH Zürich, 8093 Zürich, Switzerland. hilvert@org.chem.ethz.ch dkern@brandeis.edu.
  • Kern D; Howard Hughes Medical Institute and Department of Biochemistry, Brandeis University, Waltham, MA 02454, USA. hilvert@org.chem.ethz.ch dkern@brandeis.edu.
Science ; 370(6523): 1442-1446, 2020 12 18.
Article em En | MEDLINE | ID: mdl-33214289
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas / Desenho Assistido por Computador / Evolução Molecular Direcionada / Enzimas / Biocatálise Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas / Desenho Assistido por Computador / Evolução Molecular Direcionada / Enzimas / Biocatálise Idioma: En Ano de publicação: 2020 Tipo de documento: Article