Dual-Target Inhibitors of the Folate Pathway Inhibit Intrinsically Trimethoprim-Resistant DfrB Dihydrofolate Reductases.

Toulouse, Jacynthe L; Shi, Genbin; Lemay-St-Denis, Claudèle; Ebert, Maximilian C C J C; Deon, Daniel; Gagnon, Marc; Ruediger, Edward; Saint-Jacques, Kévin; Forge, Delphine; Vanden Eynde, Jean Jacques; Marinier, Anne; Ji, Xinhua; Pelletier, Joelle N.

Afiliação

Toulouse JL; Département de biochimie, Université de Montréal, Montréal, Quebec H3T 1J4, Canada.
Shi G; PROTEO, Quebec G1V 0A6, Canada.
Lemay-St-Denis C; CGCC, Center in Green Chemistry and Catalysis, Montréal, Quebec H2V 0B3, Canada.
Ebert MCCJC; Macromolecular Crystallography Laboratory, NCI, Frederick, Maryland 21702, United States.
Deon D; Département de biochimie, Université de Montréal, Montréal, Quebec H3T 1J4, Canada.
Gagnon M; PROTEO, Quebec G1V 0A6, Canada.
Ruediger E; CGCC, Center in Green Chemistry and Catalysis, Montréal, Quebec H2V 0B3, Canada.
Saint-Jacques K; Chemical Computing Group ULC, Montréal, Quebec H3A 2R7, Canada.
Forge D; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Quebec H3T 1J4, Canada.
Vanden Eynde JJ; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Quebec H3T 1J4, Canada.
Marinier A; Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Quebec H3T 1J4, Canada.
Ji X; Département de chimie, Université de Sherbrooke, Sherbrooke, Quebec J1K 2R1, Canada.
Pelletier JN; Laboratoire de chimie organique, Université de Mons, 7000 Mons, Belgium.

ACS Med Chem Lett ; 11(11): 2261-2267, 2020 Nov 12.

Article em En | MEDLINE | ID: mdl-33214838

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article