Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2, Colombia.
Emerg Infect Dis
; 26(12): 2854-2862, 2020 12.
Article
em En
| MEDLINE
| ID: mdl-33219646
ABSTRACT
Coronavirus disease (COVID-19) in Colombia was first diagnosed in a traveler arriving from Italy on February 26, 2020. However, limited data are available on the origins and number of introductions of COVID-19 into the country. We sequenced the causative agent of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from 43 clinical samples we collected, along with another 79 genome sequences available from Colombia. We investigated the emergence and importation routes for SARS-CoV-2 into Colombia by using epidemiologic, historical air travel, and phylogenetic observations. Our study provides evidence of multiple introductions, mostly from Europe, and documents >12 lineages. Phylogenetic findings validate the lineage diversity, support multiple importation events, and demonstrate the evolutionary relationship of epidemiologically linked transmission chains. Our results reconstruct the early evolutionary history of SARS-CoV-2 in Colombia and highlight the advantages of genome sequencing to complement COVID-19 outbreak investigations.
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Base de dados:
MEDLINE
Assunto principal:
Filogenia
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Genoma Viral
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Genômica
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SARS-CoV-2
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COVID-19
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article