Malnutrition is independently associated with an increased risk of major cardiovascular events in adult patients with congenital heart disease.
Nutr Metab Cardiovasc Dis
; 31(2): 481-488, 2021 02 08.
Article
em En
| MEDLINE
| ID: mdl-33223403
ABSTRACT
BACKGROUND AND AIMS:
Malnutrition is found frequently during chronic diseases, and its prevalence and relation to disease outcome in adult patients with congenital heart disease (CHD) remains unknown. METHODS ANDRESULTS:
A cohort of 393 consecutive stable congenital heart disease (CHD) patients was followed up in a single dedicated clinical unit. Demographic, clinical and laboratory parameters, along with a nutritional risk index (NRI), were studied, as well as major acute cardiovascular events (MACE), defined as arterial thrombotic events, heart failure requiring hospitalization or cardiovascular and non-cardiovascular mortality. The median age of the patients was 23 years (17-35) and 225 (57%) were males. Median plasma albumin concentration was 4.5 (4.2-4.7) g/dL, the body mass index was 23 (21-27) kg/m2, the NRI was 112 (106-118), and 33 (8%) patients showed malnutrition (NIR<100). A worse NYHA functional class (II and III), total cholesterol and serum glucose levels were significant risk factors associated with malnutrition (NRI<100) in CHD patients. During a median follow-up of 8 (5-10) years, 39 (10%) CHD patients suffered a MACE. Multivariable Cox regression analysis showed that older patients (years) [HR 1.06 (1.04-1.09), p < 0.001], CHD patients with great anatomical complexity [HR 4.24 (2.17-8.27), p < 0.001] and those with a lower NRI [HR 0.95 (0.93-0.98), p = 0.001] had a significant worse MACE-free survival, being the NRI a better predictor of MACE than albumin concentration.CONCLUSIONS:
A low NRI is independently associated with a significant increased risk of MACE in CHD patients.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Estado Nutricional
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Sobreviventes
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Desnutrição
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Cardiopatias Congênitas
Idioma:
En
Ano de publicação:
2021
Tipo de documento:
Article