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Ribociclib in Breast Cancer Brain Metastases: A Case Report.
Radke, Isabel; von Wahlde, Marie-Kristin; Schülke, Christoph; Tio, Joke.
Afiliação
  • Radke I; Department of Gynecology and Obstetrics, University Hospital of Münster, Münster, Germany.
  • von Wahlde MK; Department of Gynecology and Obstetrics, University Hospital of Münster, Münster, Germany.
  • Schülke C; Department of Radiology, University Hospital of Münster, Münster, Germany.
  • Tio J; Department of Gynecology and Obstetrics, University Hospital of Münster, Münster, Germany.
Breast Care (Basel) ; 15(5): 543-547, 2020 Oct.
Article em En | MEDLINE | ID: mdl-33224000
INTRODUCTION: Breast cancer is the most common cancer in women. It frequently metastasizes to the lung, liver, and bones. Due to the improvement of therapeutic strategies and therefore longer patient survival, brain metastases have become more frequent. However, evidence-based therapeutic options of systemic treatment are limited because patients with breast cancer brain metastases are often excluded from clinical trials. CASE PRESENTATION: Here, we show a patient with brain and orbital metastases from a hormone receptor-positive, Her2neu-negative breast cancer that led to one-sided blindness. She was treated with a combination therapy of the CDK4/6 inhibitor ribociclib and the aromatase inhibitor anastrozole and showed a fast and durable response for 9 months with good tolerability of the treatment. CONCLUSION: Systemic treatment with a CDK4/6 inhibitor and endocrine therapy can be considered in breast cancer brain metastases.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article