Centrosome defects cause microcephaly by activating the 53BP1-USP28-TP53 mitotic surveillance pathway.

Phan, Thao P; Maryniak, Aubrey L; Boatwright, Christina A; Lee, Junsu; Atkins, Alisa; Tijhuis, Andrea; Spierings, Diana Cj; Bazzi, Hisham; Foijer, Floris; Jordan, Philip W; Stracker, Travis H; Holland, Andrew J

Phan, Thao P; Maryniak, Aubrey L; Boatwright, Christina A; Lee, Junsu; Atkins, Alisa; Tijhuis, Andrea; Spierings, Diana Cj; Bazzi, Hisham; Foijer, Floris; Jordan, Philip W; Stracker, Travis H; Holland, Andrew J.

Afiliação

Phan TP; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Maryniak AL; Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Boatwright CA; Johns Hopkins University, Baltimore, MD, USA.
Lee J; Johns Hopkins University, Baltimore, MD, USA.
Atkins A; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Tijhuis A; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Spierings DC; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Bazzi H; Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Foijer F; Department of Dermatology and Venereology, University Hospital of Cologne, Köln, Germany.
Jordan PW; European Research Institute for the Biology of Ageing, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Stracker TH; Department of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Holland AJ; Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain.

EMBO J ; 40(1): e106118, 2021 01 04.

Article em En | MEDLINE | ID: mdl-33226141

Assuntos

Centrossomo/metabolismo; Microcefalia/genética; Microcefalia/metabolismo; Mitose/genética; Proteína Supressora de Tumor p53/genética; Proteína 1 de Ligação à Proteína Supressora de Tumor p53/genética; Ubiquitina Tiolesterase/genética; Animais; Apoptose/genética; Encéfalo/patologia; Morte Celular/genética; Proliferação de Células/genética; Células Cultivadas; Camundongos; Camundongos Knockout; Mutação/genética; Transdução de Sinais/genética

Palavras-chave

DNA damage; TP53 activation; centrosome; microcephaly; mitotic surveillance pathway

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Centrossomo / Ubiquitina Tiolesterase / Proteína 1 de Ligação à Proteína Supressora de Tumor p53 / Microcefalia / Mitose Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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