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Genomic surveillance of SARS-CoV-2 in Thailand reveals mixed imported populations, a local lineage expansion and a virus with truncated ORF7a.
Joonlasak, Khajohn; Batty, Elizabeth M; Kochakarn, Theerarat; Panthan, Bhakbhoom; Kümpornsin, Krittikorn; Jiaranai, Poramate; Wangwiwatsin, Arporn; Huang, Angkana; Kotanan, Namfon; Jaru-Ampornpan, Peera; Manasatienkij, Wudtichai; Watthanachockchai, Treewat; Rakmanee, Kingkan; Jones, Anthony R; Fernandez, Stefan; Sensorn, Insee; Sungkanuparph, Somnuek; Pasomsub, Ekawat; Klungthong, Chonticha; Chookajorn, Thanat; Chantratita, Wasun.
Afiliação
  • Joonlasak K; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Batty EM; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, Unit
  • Kochakarn T; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Genomics and Evolutionary Medicine Unit (GEM), Center of Excellence in Malaria Research, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Faculty of Medicine Ramathibodi Hospital, Mahidol University Bangkok, Thai
  • Panthan B; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Kümpornsin K; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Wellcome Sanger Institute, Hinxton, Cambridgeshire, United Kingdom.
  • Jiaranai P; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Wangwiwatsin A; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Department of Biology, Faculty of Science, Khon Kaen University, Khon Kaen, Thailand.
  • Huang A; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Kotanan N; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Genomics and Evolutionary Medicine Unit (GEM), Center of Excellence in Malaria Research, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
  • Jaru-Ampornpan P; Virology and Cell Technology Research Team, National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
  • Manasatienkij W; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Watthanachockchai T; Division of Virology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Rakmanee K; Division of Virology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Jones AR; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Fernandez S; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Sensorn I; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Sungkanuparph S; Chakri Naruebodindra Medical Institute, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Samut Prakan, Thailand.
  • Pasomsub E; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Division of Virology, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
  • Klungthong C; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
  • Chookajorn T; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Genomics and Evolutionary Medicine Unit (GEM), Center of Excellence in Malaria Research, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand. Electronic address: thanat.cho@mahidol.edu.
  • Chantratita W; COVID-19 Network Investigations Alliance (CONI), Bangkok, Thailand; Center for Medical Genomics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. Electronic address: wasun.cha@mahidol.ac.th.
Virus Res ; 292: 198233, 2021 01 15.
Article em En | MEDLINE | ID: mdl-33227343
ABSTRACT
Coronavirus Disease 2019 (COVID-19) is a global public health threat. Genomic surveillance of SARS-CoV-2 was implemented in March of 2020 at a major diagnostic hub in Bangkok, Thailand. Several virus lineages supposedly originated in many countries were found, and a Thai-specific lineage, designated A/Thai-1, has expanded to be predominant in Thailand. A virus sample in the SARS-CoV-2 A/Thai-1 lineage contains a frame-shift deletion at ORF7a, encoding a putative host antagonizing factor of the virus.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Virais / Genoma Viral / SARS-CoV-2 / COVID-19 Idioma: En Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas Virais / Genoma Viral / SARS-CoV-2 / COVID-19 Idioma: En Ano de publicação: 2021 Tipo de documento: Article