Surface Acoustic Wave Sensor for C-Reactive Protein Detection.
Sensors (Basel)
; 20(22)2020 Nov 19.
Article
em En
| MEDLINE
| ID: mdl-33228249
ABSTRACT
A surface acoustic wave (SAW) sensor was investigated for its application in C-reactive protein (CRP) detection. Piezoelectric lithium niobate (LiNbO3) substrates were used to study their frequency response characteristics in a SAW sensor with a CRP sensing area. After the fabrication of the SAW sensor, the immobilization process was performed for CRP/anti-CRP interaction. The CRP/anti-CRP interaction can be detected as mass variations in the sensing area. These mass variations may produce changes in the amplitude of sensor response. It was clearly observed that a CRP concentration of 0.1 µg/mL can be detected in the proposed SAW sensor. A good fitting linear relationship between the detected insertion loss (amplitude) and the concentrations of CRP from 0.1 µg/mL to 1 mg/mL was obtained. The detected shifts in the amplitude of insertion loss in SAW sensors for different CRP concentrations may be useful in the diagnosis of risk of cardiovascular diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Som
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Proteína C-Reativa
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Doenças Cardiovasculares
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article