Comparison of the Levels of Transforming Growth Factor-ß1 in Tear Fluid in Patients with High Myopia after Transepithelial Photorefractive Keratectomy and Laser Subepithelial Keratomileusis (LASEK).
Bull Exp Biol Med
; 170(1): 79-83, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-33231800
ABSTRACT
We compared the level of transforming growth factor-ß1 (TGF-ß1) in the tear fluid of 20 patients with high myopia who underwent transepithelial photorefractive keratectomy (T-PRK) in one eye and laser subepithelial keratomileusis (LASEK) in the contralateral eye. Tear fluid samples were collected with scaled microcapillary tubes before (day 0) and on days 1, 3, and 5 after surgery. The release of TGF-ß1 was determined by multiplying the concentration of TGF-ß1 by capillary tear fluid flow. Corneal haze was also evaluated in 1, 3, and 6 months after surgeries. The median TGF-ß1 release after T-PRK and LASEK differed significantly on days 1 and 3 (p<0.005) and on day 5 (p<0.05). The mean corneal haze score after T-PRK and LASEK also significantly differed in 1 month (p<0.005), but no significant differences in this parameter were revealed at later terms. Thus, the level of TGF-ß1 in the tear fluid after T-PRK was lower than after LASEK, which can be the cause of less pronounced corneal haze in 1 month after surgery.
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MEDLINE
Assunto principal:
Lágrimas
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Ceratectomia Fotorrefrativa
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Ceratectomia Subepitelial Assistida por Laser
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Fator de Crescimento Transformador beta1
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Miopia
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article