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Comparing efficacy and safety in catheter ablation strategies for atrial fibrillation: protocol of a network meta-analysis of randomised controlled trials.
Charitakis, Emmanouil; Karlsson, Lars O; Rizas, Kostantinos; Almroth, Henrik; Hassel Jönsson, Anders; Schweiler, Jonas; Sideris, Skevos; Tsartsalis, Dimitrios; Dragioti, Elena; Chaimani, Anna.
Afiliação
  • Charitakis E; Department of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University Hospital, Linköping, Sweden emmanouil.charitakis@liu.se.
  • Karlsson LO; Department of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University Hospital, Linköping, Sweden.
  • Rizas K; Department of Cardiology, LMU München, Munchen, Germany.
  • Almroth H; Department of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University Hospital, Linköping, Sweden.
  • Hassel Jönsson A; Department of Cardiology and Department of Health, Medicine and Caring Sciences, Linköping University Hospital, Linköping, Sweden.
  • Schweiler J; Heart and Vascular Theme, Karolinska University Hospital, Stockholm, Sweden.
  • Sideris S; Department of Cardiology, Hippokration Hospital, National and Kapodistrian University of Athens, Athens, Attica, Greece.
  • Tsartsalis D; Department of Clinical Physiology, Linköping University Hospital, Linköping, Sweden.
  • Dragioti E; Pain and Rehabilitation Center and Department of Health and Caring Sciences, Linköping University, Linköping, Sweden.
  • Chaimani A; Research Center of Epidemiology and Statistics (CRESS-U1153), Univeristé de Paris, Paris, Île-de-France, France.
BMJ Open ; 10(11): e041819, 2020 11 23.
Article em En | MEDLINE | ID: mdl-33234655
ABSTRACT

INTRODUCTION:

Atrial fibrillation (AF) is the most common sustained arrhythmia. Catheter ablation (CA) of AF is an increasingly offered therapeutic approach, primary to relieve AF-related symptoms. Despite the development of new ablation approaches, there is no consensus regarding the most efficient ablation strategy. The objective of this network meta-analysis (NMA) is to compare the efficacy and safety of all different CA approaches for the treatment of patients with paroxysmal (PAF) and non-PAF (non-PAF). METHODS AND

ANALYSIS:

We will perform a systematic search to identify randomised controlled trials of different CA approaches for the treatment of PAF and non-PAF, through the final search date of 1 March 2020. Information sources will include major bibliographic databases (MEDLINE, Web of Science and CENTRAL) and clinical trial registries. Our primary outcomes will be the efficacy (recurrence-free survival) and safety of different CA approaches for the treatment of AF. Secondary outcomes will be all-cause mortality and procedural time. An NMA will be performed to determine the relative effects of different catheter ablation approaches (such as pulmonary vein isolation alone or in combination with ablation lines, ablation of complex fractionated atrial electrograms, etc). In PAF, a separate analysis will be performed including different energy sources (such as radiofrequency, cryogenic and laser energy). Risk of bias assessment and sensitivity analyses will be conducted to assess the robustness of the findings to potential bias. ETHICS AND DISSEMINATION No ethical approval will be needed because data are collected from previous studies. The results will be presented through peer-review journals and conference presentation. PROSPERO REGISTRATION NUMBER CRD42020169494.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Veias Pulmonares / Fibrilação Atrial / Ablação por Cateter Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Veias Pulmonares / Fibrilação Atrial / Ablação por Cateter Idioma: En Ano de publicação: 2020 Tipo de documento: Article