p53 and RB1 regulate Hedgehog responsiveness via autophagy-mediated ciliogenesis.
Mol Cell Oncol
; 7(6): 1805095, 2020 Sep 08.
Article
em En
| MEDLINE
| ID: mdl-33235907
ABSTRACT
Loss of tumor protein p53 (p53) and RB transcriptional corepressor 1 (RB1) in developmental and small cell lung cancer models promotes primary cilia formation and hyper-responsiveness to Hedgehog ligand. This is mediated by impaired transcription of p53 and RB1 target genes involved in autophagic degradation of primary cilia.
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MEDLINE
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En
Ano de publicação:
2020
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Article