The introduction of L-phenylalanine into antimicrobial peptide protonectin enhances the selective antibacterial activity of its derivative phe-Prt against Gram-positive bacteria.

Peng, Jinxiu; Qiu, Shuai; Jia, Fengjing; Zhang, Lishi; He, Yuhang; Zhang, Fangfang; Sun, Mengmeng; Deng, Yabo; Guo, Yifei; Xu, Zhaoqing; Liang, Xiaolei; Yan, Wenjin; Wang, Kairong

Peng, Jinxiu; Qiu, Shuai; Jia, Fengjing; Zhang, Lishi; He, Yuhang; Zhang, Fangfang; Sun, Mengmeng; Deng, Yabo; Guo, Yifei; Xu, Zhaoqing; Liang, Xiaolei; Yan, Wenjin; Wang, Kairong.

Afiliação

Peng J; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China.
Qiu S; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China.
Jia F; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China.
Zhang L; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China.
He Y; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China.
Zhang F; Key Laboratory for Gynecologic Oncology of Gansu Province, Department of Gynecology, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, People's Republic of China.
Sun M; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China.
Deng Y; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China.
Guo Y; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China.
Xu Z; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China.
Liang X; Key Laboratory for Gynecologic Oncology of Gansu Province, Department of Gynecology, The First Hospital of Lanzhou University, Lanzhou University, Lanzhou, People's Republic of China.
Yan W; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China. yanwj@lz
Wang K; Key laboratory of Preclinical Study for New Drugs of Gansu Province, Institute of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Research Unit of Peptide Science of Chinese Academy of Medical Sciences 2019RU066, Lanzhou University, Lanzhou, People's Republic of China. wangkr@l

Amino Acids ; 53(1): 23-32, 2021 Jan.

Article em En | MEDLINE | ID: mdl-33236256

Assuntos

Antibacterianos/farmacologia; Bactérias Gram-Positivas/efeitos dos fármacos; Oligopeptídeos/química; Fenilalanina/química; Proteínas Citotóxicas Formadoras de Poros/farmacologia; Venenos de Vespas/química; Antibacterianos/química; Membrana Celular/efeitos dos fármacos; Membrana Celular/metabolismo; Permeabilidade da Membrana Celular/efeitos dos fármacos; Dicroísmo Circular; Bactérias Gram-Negativas/efeitos dos fármacos; Lipopolissacarídeos/metabolismo; Testes de Sensibilidade Microbiana; Viabilidade Microbiana/efeitos dos fármacos; Oligopeptídeos/farmacologia; Proteínas Citotóxicas Formadoras de Poros/química; Venenos de Vespas/farmacologia

Palavras-chave

Antimicrobial peptide phe-Prt; Gram-negative bacteria; LPS; Selectivity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Fenilalanina / Venenos de Vespas / Proteínas Citotóxicas Formadoras de Poros / Bactérias Gram-Positivas / Antibacterianos Idioma: En Ano de publicação: 2021 Tipo de documento: Article

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